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101.
Qiaozhi Zhang Yanbo Wang Linglin Fu 《Comprehensive Reviews in Food Science and Food Safety》2020,19(5):2559-2587
Dietary advanced glycation end products (dAGEs) are complex and heterogeneous compounds derived from nonenzymatic glycation reactions during industrial processing and home cooking. There is mounting evidence showing that dAGEs are closely associated with various chronic diseases, where the absorbed dAGEs fuel the biological AGEs pool to exhibit noxious effects on human health. Currently, due to the uncertain bioavailability and rapid renal clearance of dAGEs, the relationship between dAGEs and biological AGEs remains debatable. In this review, we provide the most updated information on dAGEs including their generation in processed foods, analytical and characterization techniques, metabolic fates, interaction with AGE receptors, implications on human health and reducing strategies. Available evidence demonstrating a relevance between dAGEs and food allergy is also included. AGEs are ubiquitous in foods and their contents largely depend on the reactivity of carbonyl and amino groups, along with surrounding condition mainly pH and heating procedures. Once being digested and absorbed into the circulation, two separate pathways can be involved in the deleterious effects of dAGEs: an AGE receptor‐dependent way to stimulate cell signals, and an AGE receptor‐independent way to dysregulate proteins via forming complexes. Inhibition of AGEs formation during food processing and reduction in the diet are two potent approaches to restrict health‐hazardous dAGEs. To elucidate the biological role of dAGEs toward human health, the following significant perspectives are raised: molecular size and complexity of dAGEs; interactions between unabsorbed dAGEs and gut microbiota; and roles played by concomitant compounds in the heat‐processed foods. 相似文献
102.
与欧盟和美国标准相比,我国硫酸铝和硫酸铵标准缺少对水处理剂中有害杂质镍、锑、硒、银、吡啶、氰化物、六价铬的检测;次氯酸钠缺少对水处理剂中有害杂质汞、铬、镉、铁、镍、锑、硒、银、六价铬的检测。结合某市2019年上半年13个水厂出厂水和原水的检测数据,剔除了5项始终低于检出限的有害杂质指标,以及2项出厂水浓度低于原水浓度的有害杂质指标。建议该市硫酸铝和硫酸铵的检测项目可以在原有国标基础上增加锑、硒;次氯酸钠可以增加汞、锑、硒。 相似文献
103.
Cardiovascular disease (CVD) is a leading cause of death worldwide. Elevated concentrations of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are major lipid biomarkers that contribute to the risk of CVD. Phytosterols well known for their cholesterol-lowering ability, are non-nutritive compounds that are naturally found in plant-based foods and can be classified into plant sterols and plant stanols. Numerous clinical trials demonstrated that 2 g phytosterols per day have LDL-C lowering efficacy ranges of 8–10%. Some observational studies also showed an inverse association between phytosterols and LDL-C reduction. Beyond the cholesterol-lowering beneficial effects of phytosterols, the association of phytosterols with CVD risk events such as coronary artery disease and premature atherosclerosis in sitosterolemia patients have also been reported. Furthermore, there is an increasing demand to determine the association of circulating phytosterols with vascular health biomarkers such as arterial stiffness biomarkers. Therefore, this review aims to examine the ability of phytosterols for CVD risk prevention by reviewing the current data that looks at the association between dietary phytosterols intake and serum lipid biomarkers, and the impact of circulating phytosterols level on vascular health biomarkers. The clinical studies in which the impact of phytosterols on vascular function is investigated show minor but beneficial phytosterols effects over vascular health. The aforementioned vascular health biomarkers are pulse wave velocity, augmentation index, and arterial blood pressure. The current review will serve to begin to address the research gap that exists between the association of dietary phytosterols with CVD risk biomarkers. 相似文献
104.
105.
《International Journal of Hydrogen Energy》2020,45(3):2094-2104
Today, the utilizations of hydrogen storage systems (HSS), renewable generation units (PV and wind generation) and distributed energy units are increased in the intelligent parking lots (IPL) in order to charge the electric vehicles (EVs) with clean energy sources. In this work, the uncertainties of upstream grid price, the demand of IPL, wind speed, solar irradiation and temperature are modeled via scenario approach based on stochastic programing. Furthermore, the downside risk constraints method (DRCM) is applied to consider risk related to uncertainties to get risk-involved stochastic performance of hydrogen storage based intelligent parking lots of electric vehicles. The proposed risk-based formulation is modeled using mixed-integer linear programming (MIP) which is implemented under GAMS software and solved via CPLEX solver. Two cases namely risk-averse and risk-neutral strategies are studied and compared to show the effects of DRCM implementation. The obtained results demonstrate the expected performance cost (EPC) of IPL is slowly raised while risk-in-cost (RIC) is significantly reduced due to model of risk related to uncertainties. 相似文献
106.
Although previous research has investigated widespread use of social media, especially Facebook, by youth attending college, the conditions under which these media foster adjustment to college remain unclear. This study tested a model illuminating pathways linking social competence to college adjustment via students’ perceptions about the usefulness of Facebook and ways in which they used the medium. Self-report survey data from 321 college students (M age = 20.09; 58% female; 84% Caucasian) attending a major Midwestern university supported the proposed model, indicating that higher social competence could foster or impede college adjustment, depending upon how it was related to beliefs about the usefulness of different Facebook functions and how these perceptions, in turn, were associated with patterns of Facebook use. Findings underscore the importance of considering connections among personal attributes, perception of media effectiveness, and media behaviors in assessing the implications of social media for users’ psychosocial well-being. 相似文献
107.
The ‘project risk screening matrix’ derives from a broader effort to assist US government agency staff in reviewing proposed stream management and restoration projects more efficiently and effectively. The River Restoration Analysis Tool (RiverRAT) developed through this effort provides a thorough, comprehensive and auditable approach to review and evaluate proposed stream actions and projects ( www.restorationreview.com ). The matrix was initially developed as the first step in applying the RiverRAT, its purpose being to assist reviewers in assessing the risk to natural resources associated with a particular proposal and matching the intensity of their review to the severity of that risk. Hence, the primary application of the matrix to date has been to identify and screen out low risk projects that may be dealt with expeditiously, so freeing the time and technical resources needed to allow deep reviews of higher risk projects. A second form of screening emerged from this primary function because the matrix proved adept at identifying the minimum level of site and project characterization required to support initial risk assessment. On this basis, proposals lacking adequate information can also be screened out, being referred back to the proponent with a request for additional information. More recently, new and novel versions of the matrix, featuring modification and refinement of one or both of the original axes, have emerged to widen and refine its application to linear infrastructure (e.g. pipelines, roads, and electrical transmission lines), in‐stream structures (e.g. large wood placement and culvert removal), and pre‐application, regulatory, decision‐support tools. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. 相似文献
108.
School educators play an important role in cyberbullying management. Since scarce earlier research indicated low perceived competence of school educators in handling cyberbullying, more insight is needed in what determines their actions and how to improve these practices. This study assessed school educator practices, their perceptions and context factors from a behavior change theoretical framework, and investigated educator clusters related to this. An online survey was conducted among 451 secondary school educators (teachers, principals, school counselors). School educators mostly used recommended actions (i.e. conversations with pupils, enlisting professionals for support, parental involvement, providing supportive victim advice). Four educator clusters were identified: ‘referrers’ (65%), ‘disengaged’ educators (14%), ‘concerned’ educators (12%) and ‘use all means’ educators (9%). The first two clusters were less adept at handling cyberbullying and comprised mostly teachers, particularly indicating a need for training teachers. Our findings show a need for tailored educator training, e.g. by job position, gender, school size and grade. The behavior change theoretical framework can help target educators' particular needs. 相似文献
109.
In vivo Kinetic Biodistribution of Nano‐Sized Outer Membrane Vesicles Derived from Bacteria 下载免费PDF全文
Su Chul Jang Sae Rom Kim Yae Jin Yoon Kyong‐Su Park Ji Hyun Kim Jaewook Lee Oh Youn Kim Eun‐Jeong Choi Dae‐Kyum Kim Dong‐Sic Choi Yoon‐Keun Kim Jaesung Park Dolores Di Vizio Yong Song Gho 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(4):456-461
Evaluation of kinetic distribution and behaviors of nanoparticles in vivo provides crucial clues into their roles in living organisms. Extracellular vesicles are evolutionary conserved nanoparticles, known to play important biological functions in intercellular, inter‐species, and inter‐kingdom communication. In this study, the first kinetic analysis of the biodistribution of outer membrane vesicles (OMVs)—bacterial extracellular vesicles—with immune‐modulatory functions is performed. OMVs, injected intraperitoneally, spread to the whole mouse body and accumulate in the liver, lung, spleen, and kidney within 3 h of administration. As an early systemic inflammation response, increased levels of TNF‐α and IL‐6 are observed in serum and bronchoalveolar lavage fluid. In addition, the number of leukocytes and platelets in the blood is decreased. OMVs and cytokine concentrations, as well as body temperature are gradually decreased 6 h after OMV injection, in concomitance with the formation of eye exudates, and of an increase in ICAM‐1 levels in the lung. Following OMV elimination, most of the inflammatory signs are reverted, 12 h post‐injection. However, leukocytes in bronchoalveolar lavage fluid are increased as a late reaction. Taken together, these results suggest that OMVs are effective mediators of long distance communication in vivo. 相似文献
110.
陈彦名 《电信工程技术与标准化》2015,(5)
介绍了目前最炙手可热的REST架构风格,该风格顺应Web2.0的兴起,完美的匹配了云计算时代来临的可扩展要求,在各种应用场景中都得到了充分的表现。根据其技术特点,分析了该风格的API在移动通信网络管理中的应用,从网管系统内部、网管系统之间以及网管系统与上层APP应用之间等多方面对是否适用于REST风格以及如何在合适的位置使用REST API进行了分析。 相似文献